Endocrine Abstracts

Autoimmune Addison’s disease (AAD) is an endocrine disease resulting from the immune system’s destruction of hormone producing cells in the adrenal cortex. Autoantibodies against the steroidogenic enzyme 21-hydroxylase (21OH) is the hallmark of this form, and found in about 85 percent of patients in European populations. Risk factors are both genetic and presumably environmental. Genes associated with AAD are MHC class II especially the DR locus, MHC class I and MIC-...

Objective: The purpose of this study was to investigate the 25-hydroxyvitamin (25(OH)D3) levels in general population.Introduction: Vitamin D is important for normal bone health. Vitamin D deficiency is a well-known cause of rickets in children and osteomalacia in adults, and it is also of importance for development of osteoporosis. Beyond this, vitamin D deficiency is suggested as a contributing factor in the development of several other diseases and co...

Introduction: The aim of our experimental study was to investigate the effect of both T2DM and metformin treatment on myocardial tolerance to ischemia-reperfusion injury and cardiac AMP-activated protein kinase (AMPK) activity.Methods: The protocol included four groups: i) controls (n=13) – non-diabetic rats treated with i.p. vehicle injections for 3 days prior to the heart perfusion, ii) controls+metformin (CM; n=12) – non-diabet...

Introduction: There are concerns about the combined estrogenic effects of endocrine disrupting chemicals (EDCs), since mixtures of these chemicals exist in our environment. This study investigated potential synergistic interactions between bisphenol A (BPA) and isobutylparaben (IBP), which are major xenoestrogens used in the manufacture of plastics, cosmetics, drugs, and other products. The combined effects of these two chemicals were analyzed by measuring expression of calbin...

Studies into estrogen receptor alpha (ERα), progesterone receptor (PGR) and the androgen receptor (AR) involvement in breast, uterine and prostate cancers has provided considerable insight into the molecular actions these receptors, but have thus far focused on each receptor individually and alone in different cell types. Here, whole genome expression microarray analysis and ChIP-sequencing in ZR-75-1 breast cancer cells, in response to combinations of 17β-estradiol ...

The allergic sensitization represents an environmental factor for thyroid autoimmunity and highlights a common pathway between autoimmunity and allergy. Elevated IgE levels are connected to hyperthyroid Graves’ disease. The allergic sensitization in thyroid autoimmunity seems mainly to be an associated immune reaction.Allergic sensitization to 20 aeroallergens and the levels of thyroid hormones and antibodies were studied in 121 patients with Graves...

Congenital hypoplastic anemia (Diamond-Blakfan Syndrom) is genetically determined disorder which is manifested in early childhood with selective deficiency of erythrocyte line in bone marrow. Severe anemia usually appears between 2nd and 6th month of life. Survival depends on blood transfusions, which in consequence lead to hemosiderosis. Hypopituitarism, hypogonadism and diabetes mellitus and other endocrinopathies are the complications of hemochromatosis.<p class="abstex...

Background: The Olsztyn region, in the north-east of Poland, is mainly a rural area with the population of 0.77 mln. After the Chernobyl breakdown the region was classified as one of the most heavily radioactively contaminated areas of Poland. It was also characterized by mild severity of iodine deficiency and endemic goiter before iodine prophylaxis introduction in 1996/7.Aim of the study: To evaluate the incidence rate (IR), current trend and histotype...

Aim: The aim of the study was to assess the effect of environmental and socio-economical factors on the increase in the incidence rate of thyroid cancer observed in Olsztyn and the Warmia and Mazury Region in the years 1994-2003.Material and methods: In the group of patients registered in the standardized thyroid cancer register their place of residence, education level, place of parents descent, exposure to ionizing irradiation during the Chernobyl acci...

Thyroid eye disease (TED) represents the most frequent and important extrathyroidal manifestation of Graves' disease. Less commonly the eye changes may occur in euthyroid individuals without a preceding history of thyrotoxicosis, represents approximately 8-21% of TED cases. Patients with the rare combination of primary hypothyroidism and TED are predisposed to severe eye disease and atypical presentation of such patients may delay diagnosis and treatment . The primary importan...